Scientist, Biomolecular Interactions in Burnaby

Join Amgen’s Mission of Serving Patients. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas – Oncology, Inflammation, General Medicine, and Rare Disease – we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity-related conditions.

As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller, happier lives. Our award-winning culture is collaborative, innovative, and science-based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

In this vital role, you will join Amgen BC’s affinity team in the In Vitro Pharmacology group to discover novel therapeutic antibodies. Our small team specializes in designing and conducting both high throughput and smaller, custom biophysical screening assays to rank and characterize both discovery and later stage large molecule therapeutic programs. The individual will join a team of dedicated scientists to discover and characterize molecules that have the potential to help patients in need. A well-suited applicant will have great laboratory skills, a strong analytical mindset, deep scientific curiosity, and a can-do attitude. The successful candidate will be responsible for the development, optimization, and implementation of various biophysical based screening assays for novel therapeutic candidates with guidance from the lead Scientist.

Essential Functions:

• Conduct routine and novel affinity/kinetic characterization screens on all relevant platforms (Carterra, Octet, Biacore, KinExA), including custom assays and assay development.
• Instrument housekeeping, reagent ordering, troubleshooting.
• Data summarizing and reporting (ELN, Screener, Benchling, slide decks), timely documentation.

Basic Qualifications:

• Doctorate degree OR Master’s degree & 3 years of related experience OR Bachelor’s degree & 5 years of directly related experience.

Preferred Qualifications:

• Deep understanding of molecular binding interaction theory (SPR, BLI), hands-on experience and instrumentation nuances – specifically Biacore, ideally 1K/8K series, KinExA experience strongly preferred.
• A good understanding of protein chemistry and/or a general biochemistry background; antibody experience desired.
• Experience with mammalian cell culture (CHO, HEK) and transfection; on-cell affinity assays or FACS is preferred.
• Experience with data analysis using PRISM, Codex and custom R/Python is an asset.
• A keen eye and a strong analytical mindset, with an interest and aptitude for DoE tasks (e.g. assay dev/troubleshooting) and data analysis and interpretation.
• Ability to multitask and stay organized in the face of shifting priorities without losing focus.

Amgen is proud to have been recognized as one of LinkedIn Top 25 Companies in Canada for career growth. In addition to the base salary, Amgen offers competitive and comprehensive Total Rewards Plans that are aligned with local industry standards. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.